Spravato® Treatment Overview

About Spravato®

Spravato® is a prescription nasal spray used in the treatment of certain forms of depression in adults. It contains esketamine as its active ingredient and is administered in combination with an oral antidepressant. This therapy works differently from traditional antidepressants by targeting NMDA receptors in the brain, which may help improve mood in some individuals who have not responded to other treatments.

Because of specific safety requirements, Spravato® is only available at certified treatment centers through a restricted program (REMS) and must be administered under the supervision of a qualified healthcare provider. Our clinic is an approved Spravato® treatment site, allowing us to offer this option as part of a broader range of mental health services.

Our Role in Your Care

We function as an adjunct treatment provider rather than a traditional therapy practice. This means we collaborate with outside therapists and accept referrals for patients who may benefit from Spravato® but are unable to access it through their primary provider.

Our Clinic

We offer private rooms for our patients during Spravato treatments. Each room is equipped with a fully-reclining heat and massage chair, galaxy light, soft blanket, and noise-cancelling Bluetooth headphones.

Eligibility Criteria

Spravato® is FDA-approved for:

• Adults with treatment-resistant depression (TRD)

• Adults with major depressive disorder (MDD) who are experiencing suicidal thoughts or behaviors

Patients must have a qualifying diagnosis to be considered for treatment.

Medication Requirements

In addition to diagnosis, insurance approval typically requires:

• Current use of one oral antidepressant

• Prior trials of at least two other antidepressants at appropriate doses and durations during the current depressive episode

Patients who do not meet these criteria may not qualify for Spravato® through insurance at this time.

Treatment Process

Getting Started

• Complete a pre-approval assessment to determine eligibility

• If approved, enroll in the treatment program

Treatment Schedule

• Weeks 1–4: Two sessions per week

• Weeks 5–8: One session per week

• Maintenance phase: Weekly or every other week, depending on response

Each appointment requires a minimum of two hours in the clinic for monitoring and safety.

Duration of Treatment

The length of therapy varies by individual and is based on:

• Symptom improvement

• Stability of response

Your provider will work with you to determine the appropriate duration and maintenance schedule.